Abstract:
The rapid development in micro/nanomaterials has brought great opportunities to disease theranostics and biosensing applications. Stimuli-responsive, multi-functional nanoscale platforms by taking advantage of the intracellular milieu or external stimuli have especially received considerable attention because of their potential in the improvement of conventional chemotherapeutics. A controlled texture or the chemical functionalization is usually coupled with adaptive properties, such as pH-, redox-, light-, and magnetic field triggered responses. I will provide a summarized overview of our recent studies in various nanoplatforms including silica and nanocarbon-based systems developed for various purposes. Their intrinsic physical/chemical properties are of critical importance to enable smart sensing and monitoring. Current success exhibited the potential and new direction to future drug delivery and bioanalytical applications. Several studies have implied their underlying therapeutic efficacy. Detailed and long-term in vivo clinical evaluations shall facilitate these bench-made materials compatible in real bedside.