Abstract:
During the last decade, a rapid increase in the use of small-angle X-ray scattering (SAXS) for non-crystalline biomolecular structures has driven a quick growth of dedicated Bio-SAXS beamlines at synchrotron facilities worldwide. Consequently, increasingly large amount of BioSAXS-related results, complimentary to that from traditional tools of X-ray crystallography, NMR, and/or other spectroscopis, have impacted greatly the research of structural biology. Embroiled with such environment, National Synchrotron Radiation Research Center (NSRRC) together with Academia Sinica have launched a joint project to develop BioSAXS facility for cutting-edge researches on, such as, solution structures of proteins and protein complexes, conformational changes of protein-protein or protein-DNA assemblies under in situ environmental stimulation, protein/membrane structural kinetics, and hierarchical biology textures. This talk will cover a recent upgrade of the current SAXS beamline with the Taiwan light Source (TLS) at NSRRC for immediate BioSAXS applications, and the conceptual design of the dedicated, state-of-the-art 13A-BioSAXS beamline of an undulator X-ray source of the 3-GeV Taiwan photon source (TPS).
Brief Bio:
Dr. U-Ser Jeng is Researcher of National Synchrotron Radiation Research Center, and Adjunct Professor of Department of Chemical Engineering, National Tsing-Hua University. He obtained his bachelor's degree from Suchow University in 1985, master's degree from National Tsing Hua University in 1987, and PhD degree from University of Rhode Island in 1996. He has been interested in small/wide angle X-rays scattering instrumentation, and X-ray and Neutron scattering on soft matter and nanomaterials: protein folding-unfolding, polymer crystallization, Lipid vesicles membranes complex, and Langmuir and Langmuir-Blodgett films. His small-angle X-ray beam is among the best in the world and currently the review-panel member of MoST Phys. Division.